Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis
نویسندگان
چکیده
INTRODUCTION Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD). Tamoxifen has been generally well-tolerated, even without randomized controlled trials. CASE PRESENTATION Herein, we report a case of a patient undergoing 12 years of PD who developed EPS and calciphylaxis simultaneously. We also provide a comprehensive discussion about the association between EPS and calciphylaxis. Moreover, although tamoxifen is used in EPS due to its inhibition of fibroblast-transforming growth factor beta (TGFβ) production, it may worsen the calciphylaxis due to a hypercoagulable state. CONCLUSIONS We suggest avoiding the use of tamoxifen for EPS in patients with superimposed calciphylaxis.
منابع مشابه
A worrying thought--could there be a connection between encapsulating peritoneal sclerosis, tamoxifen and calciphylaxis?
Encapsulating peritoneal sclerosis (EPS) is a serious problem for chronically dialysed patients [1,2]. With an overall prevalence of 2–3% in patients undergoing peritoneal dialysis (PD), it is now obvious that extended duration of PD therapy increases the incidence and severity of EPS [3]. Mortality rates in patients with EPS remain high—especially after bowel obstruction becomes an overt probl...
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